This Article Full Text (PDF) All Versions of this Article: 1066896908316069v1 17/1/42    most recent References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Chanjuan Shi Articles by Argani, P. Search for Related Content PubMed PubMed Citation Articles by Chanjuan Shi, Articles by Argani, P. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Skin Cancer Social Bookmarking                         What's this?

Synchronous Primary Perianal Paget's Disease and Rectal Adenocarcinoma: Report of a Hitherto Undescribed Phenomenon

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, Maryland

Pedram Argani, MD

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, pargani{at}jhmi.edu

Perianal Paget's disease is rare. It usually represents intraepidermal extension of an invasive carcinoma from an adjacent internal organ, but some cases represent primary intraepithelial cutaneous apocrine adenocarcinomas. Here, we report a unique case, which we interpret as synchronous primary perianal Paget's disease and lower rectal adenocarcinoma. Immunohistochemical stains demonstrated that the Paget's cells were CK7⁺/ CK20^–/GCDFP⁺, whereas the rectal adenocarcinoma was CK7⁺(variable)/CK20⁺/GCDFP ^–. This discordant immunoprofile supported our impression that the Paget's disease in this patient was of cutaneous apocrine origin rather than a pagetoid extension from the patient's nearby rectal adenocarcinoma—to our knowledge a hitherto undocumented occurrence.

Key Words: primary Paget's disease • perianal • rectal adenocarcinoma

This version was published on February 1, 2009

International Journal of Surgical Pathology, Vol. 17, No. 1, 42-45 (2009)
DOI: 10.1177/1066896908316069


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?