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International Journal of Surgical Pathology
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Article

Correlation Between Thymidylate Synthase Protein Expression and Gene Polymorphism With Clinicopathological Parameters in Colorectal Carcinoma

Luciana R Moreira*, André Almeida Schenka, Paulo Latuff Filho, Helvia Nascimento, Carmen Carmen Silvia Passos Lima, Miriam Aparecida Silva Trevisan, and José Vassallo

* To whom correspondence should be addressed. E-mail: lu.patologia{at}uol.com.br.


  Abstract
5-Fluorouracil (5-FU) represents the basis of chemotherapy for colorectal carcinoma, inhibiting thymidylate synthase (TS), an essential enzyme for DNA replication. Previous studies have associated high TS protein expression by tumor cells with poor outcome of patients with colorectal carcinoma, but others have refuted these findings. In view of the potential role of TS as predictive parameter and the lack of consensus in the literature, the present study compared 2 methods: protein expression and gene polymorphism, correlating them with clinicopathological findings. Immunohistochemical detection of TS in tumor cells and detection of gene polymorphism in the blood were performed in 32 patients with colorectal carcinoma treated with 5-FU. No correlation was found between TS protein expression and gene polymorphism. Neither method correlated with survival, tumor staging, and tumor histological grading. This result possibly reflects a complex tumor response to 5-FU therapy, where TS is just one of the involved proteins.

First published on January 14, 2009, doi:10.1177/1066896908330480

International Journal of Surgical Pathology 2009;17:181.

A more recent version of this article appeared on June 1, 2009

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