Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to browse AJSM online!

Sign In to gain access to subscriptions and/or personal tools.
International Journal of Surgical Pathology
This Article
Right arrow Full Text (OnlineFirst PDF)
Right arrow All Versions of this Article:
1066896907311901v1
16/2/119    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Sze-Chuen Wong, C.
Right arrow Articles by Tak-Cheung Chan, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sze-Chuen Wong, C.
Right arrow Articles by Tak-Cheung Chan, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Article

Isolated Tumor Cells and Circulating CK20 mRNA in pN0 Colorectal Cancer Patients

Cesar Sze-Chuen Wong*, Mong-Tong Cheung, Brigette Buig-Yue Ma, Edwin Pun Hui, Alex Chak-Lam Chan, Chi-Kin Chan, King-Chung Lee, Wah Cheuk, Money Yan-Yee Lam, Manson Chi-Keung Wong, Charles Ming-Lok Chan, John Kwok-Keung Chan, and Anthony Tak-Cheung Chan

* To whom correspondence should be addressed. E-mail: cesar01{at}netvigator.com.


  Abstract
Micrometastases in lymph nodes and blood may provide important prognostic information. In this study, cytokeratin 20 (CK20) positive cells in lymph nodes and circulating CK20 mRNA were studied using 57 paraffin-embedded lymph node specimens and blood from 24 patients with pN0 colorectal cancer (CRC), respectively. Results showed that 29 out of 56 (52%) lymph node specimens had CK20-positive cells (range: 1-35). Follow-up of the patients for 12 months indicated that 4 patients (7%) had CRC metastases to liver, lung, and bone. In addition, 8 out of 24 (33%) samples had at least 2-fold circulating CK20 mRNA expression higher than the pooled normal sample. This study provides evidence that CK20-positive cells were found in the lymph nodes and differentially expressed circulating CK20 mRNA was also detected in the blood from patients with pN0 CRC. Long-term follow-up is necessary to study their prognostic use in patients with non-metastatic CRC.

First published on April 2, 2008, doi:10.1177/1066896907311901

International Journal of Surgical Pathology 2008;16:119.

A more recent version of this article appeared on April 1, 2008

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 INT J SURG PATHOLHome page
G. D'Armento, L. Daniele, S. Mariani, D. Ottaviani, A. Mussa, P. Cassoni, A. Sapino, and G. Bussolati
Added Value of Combined Gene and Protein Expression of CK20 and CEA in Non--macroscopically Involved Lymph Nodes of Colorectal Cancer
International Journal of Surgical Pathology, April 1, 2009; 17(2): 93 - 98.
[Abstract] [PDF]