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Prevalence of RET/PTC Rearrangements in Hashimoto's Thyroiditis and Papillary Thyroid Carcinomas

Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH, USA.

Christy M. Caudill, BS

Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH, USA.

Paul Biddinger, MD

Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH, USA.

Yuri E. Nikiforov, MD, PhD

Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH, USA.

The relationship between Hashimoto's thyroiditis (HT) and follicular cell-derived thy roid cancer remains unclear. Recently, 2 studies reported a 95% prevalence of RET/PTC rearrangements in histologically benign tissue affected by HT, suggesting that multiple occult tumors exist in HT patients with high frequency. We tested the prevalence of RET/PTC rearrangements in 26 HT, in 6 papillary carcinomas arising in the background of HT, and in 27 papillary carcinomas not associated with HT. We detected no RET/PTC rearrangements in HT or papillary carcinomas arising in the background of HT, in contrast to a 33% prevalence among papillary carcinomas not associated with HT. However, the expression of wild-type RET was found in more than half of papillary carcinomas. These results suggest that, if the association be tween HT and thyroid cancer exists, its molecular basis is different from RETIPTC rearrangement. Int J Surg Pathol 10(1):15-22, 2002

Key Words: thyroid • Hashimito's thyroiditis • papillary carcinoma • RET gene • RET/PTC rearrangement.

International Journal of Surgical Pathology, Vol. 10, No. 1, 15-22 (2002)
DOI: 10.1177/106689690201000104


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