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Multiple Lymphomatous Diverticulosis and Comorbid Chronic Lymphocytic Leukemia: Novel Manifestations of Ileocolic Mantle Cell Lymphoma

Department of Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada, shaun.medlicott{at}cls.ab.ca

Holly A. Brown, MD

Department of Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada

Birgitte Roland, MD

Department of Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada

Paul L. Beck, MD

Department of Gastroenterology, University of Calgary, Calgary, Alberta, Canada

Iwona Auer, MD

Department of Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada

Adnan Mansoor, MD

Department of Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada

Mantle cell lymphoma (MCL) has tropism for the gastrointestinal tract (GIT) identifiable as multiple polyps and mass lesions throughout the GIT. We describe 2 novel manifestations of MCL. A 60-year-old woman with known chronic lymphocytic leukemia (CLL) had an exophytic mass of the appendiceal orifice. Multiple polypoid masses of the distal ileum were identified in the right hemicolectomy specimen (multiple lymphomatous polyposis). Ancillary studies confirmed the coexistence of the 2 independent lymphoproliferative disorders. A 69-year-old man had recurrent urinary tract infections and pneumatouria caused by a colovesicular fistula complicating diverticulosis coli. Segmental resections of the sigmoid and ileocecum confirmed diverticulosis of the left and right colon. Histology identified infiltrates of MCL confined to the penetrating aspects of colonic diverticula. MCL has not been documented to coexist with CLL. An invaginating morphology of lymphoma, multiple lymphomatous diverticulosis is also a novel presentation. These 2 scenarios expand MCL's known manifestations within the GIT.

Key Words: mantle cell lymphoma • diverticulosis • chronic lymphocytic leukemia

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International Journal of Surgical Pathology, Vol. 15, No. 4, 408-413 (2007)
DOI: 10.1177/1066896907302372


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Medlicott, S. A. C. Articles by Mansoor, A. Search for Related Content PubMed PubMed Citation Articles by Medlicott, S. A. C. Articles by Mansoor, A. Social Bookmarking                         What's this?