Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
International Journal of Surgical Pathology
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
1066896908323506v1
17/5/390    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ozbudak, I. H.
Right arrow Articles by Demircan, A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ozbudak, I. H.
Right arrow Articles by Demircan, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Vascular Endothelial Growth Factor Expression and Neovascularization in Non—Small Cell Lung Carcinoma

Irem Hicran Ozbudak, MD

Department of Pathology, Akdeniz University School of Medicine, Antalya, iremhicrang{at}hotmail.com

Gulay Ozbilim, MD

Department of Pathology, Akdeniz University School of Medicine, Antalya

Ilknur Kucukosmanoglu, MD

Erzurum Numune Hospital Erzurum, Turkey

Levent Dertsiz, MD

Department of Chest Surgery, Akdeniz University School of Medicine, Antalya

Abid Demircan, MD

Department of Chest Surgery Akdeniz University School of Medicine, Antalya

The prognostic significance of microvascular density (MVD) and vascular endothelial growth factor (VEGF) expression were investigated in 15 patients with adenocarcinoma (AC) and 15 patients with squamous cell carcinoma (SCC). Immunohistochemically, VEGF and factor VIII were applied. The average microvessel counts were given as MVD, and VEGF expression was given as VEGF percentage area and VEGF staining degree. Higher values of MVD were obtained in patients with AC (11.47 ± 3.48) when compared with patients with SCC (7.47 ± 2.50; P = .001) and also in patients at early stages of disease (10.77 ± 3.24) when compared with patients at advanced stages (8.47 ± 3.64; P = .050). A significant correlation was shown between MVD and VEGF percentage area (P = .006) and between VEGF percentage area and VEGF staining degree (P = .000). No significant difference was found in VEGF percentage area between patients with SCC and AC and between patients at early and advanced stages. In conclusion, VEGF or MVD should not be regarded as a solitary prognostic factor but should be supported by other prognostic factors.

Key Words: non—small cell lung carcinoma • vascular endothelial growth factor • VEGF • angiogenesis

This version was published on October 1, 2009

International Journal of Surgical Pathology, Vol. 17, No. 5, 390-395 (2009)
DOI: 10.1177/1066896908323506
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?