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International Journal of Surgical Pathology
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Tissue Eosinophilia and its Association with Tumoral Invasion of Oral Cancer

Denise Tostes Oliveira, DDS, PhD

Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, dtostes44{at}yahoo.com

Kellen Cristine Tjioe, DDS

Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo

Agnes Assao, DDS

the Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo

Simone Eloiza Sita Faustino, DDS, MSc

the Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo

André Lopes Carvalho, MD, PhD

Department of Head and Neck Surgery and Otorhinolaryngology, A. C. Camargo Cancer Hospital

Gilles Landman, MD, PhD

Department of Pathology, A. C. Camargo Cancer Hospital São Paulo, Brazil

Luiz Paulo Kowalski, MD, PhD

Department of Head and Neck Surgery and Otorhinolaryngology, A. C. Camargo Cancer Hospital

This study investigated if tumor-associated tissue eosinophilia (TATE) could be associated with the process of tissue invasion in oral squamous cell carcinomas (OSCCs) and its influence on patient's prognosis. Forty-three patients treated for OSCCs with or without lymph nodes involvement, at A. C. Camargo Cancer Hospital, Brazil, were selected for TATE analysis. Two degrees of tissue eosinophilia were established in OSCC: absent/mild and intense. The TATE was evaluated in relation to the clinicopathological features and prognostic value using {chi} 2 test and the Kaplan—Meier method. Most of the patients with OSCC in advanced clinical stage presented muscular infiltration and significantly intense TATE whereas those with tumors in early stage frequently showed absent/mild eosinophilia (P = .009). The TATE showed no prognostic value for 5-year and 10-year survival rates of the OSCC. These findings suggest that intense TATE seems to reflect the stromal invasion of the OSCCs that occur in advanced clinical stage.

Key Words: oral cancer • tissue eosinophilia • eosinophils • cancer

International Journal of Surgical Pathology, Vol. 17, No. 3, 244-249 (2009)
DOI: 10.1177/1066896909333778
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