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International Journal of Surgical Pathology
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*Kidney Cancer
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Heavily Pigmented Renal Cell Carcinoma: A Case Report, With Review of the Literature and Differential Diagnosis

Giulio Rossi, MD

Section of Pathologic Anatomy, Azienda Policlinico, Modena, Italy, rossi.giulio{at}policlinico.mo.it

Annamaria Cadioli, MD

Section of Pathologic Anatomy, Azienda Policlinico, Modena, Italy

Matteo Costantini, MD

Section of Pathologic Anatomy, Azienda Policlinico, Modena, Italy

Maria Grazia Del Buono, MD

Section of Gastroenterology, Azienda Policlinico, Modena, Italy

Giorgio Oleari, MD

Section of Urology, Azienda Policlinico, Modena, Italy

Clear cell carcinoma is the most common histotype among renal cell tumors. The prominent vascular network of sinusoidal vessels lined by delicate endothelial cells may often lead to hemorrhagic areas with secondary deposition of chunky birefringent hemosiderin granules. The finding of pigmentation other than iron, and in particular melanin deposits, in renal tumors is a rare occurrence that should lead to differential diagnosis with other primary and metastatic tumors of the kidney.

Key Words: kidney • melanin • carcinoma • cytokeratin • HMB45 • angiomyolipoma

This version was published on April 1, 2009

International Journal of Surgical Pathology, Vol. 17, No. 2, 167-169 (2009)
DOI: 10.1177/1066896908316787
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