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International Journal of Surgical Pathology
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Plasmablastic Lymphoma Affecting the Lung and Bone Marrow With CD10 Expression and t(8;14)(q24;q32) Translocation

Khoon Leong Chuah, MBBS, FRCPA

Department of Pathology Tan Tock Seng Hospital, Singapore, gzzckl{at}singnet.com.sg

Siok Bian Ng, MBBS, FRCPA

Department of Pathology, National University Hospital, Singapore

Limei Poon, MBBS, MRCP

Department of Haematology, National University Hospital, Singapore

Wai Ming Yap, MBBS, FRCPath

Department of Pathology Tan Tock Seng Hospital, Singapore

Plasmablastic lymphoma is a rare variant of a diffuse, large B-cell lymphoma, which typically presents in the oral cavity in immunocompromised patients. In HIV positive patients, this tumor has a tendency to manifest in extramedullary sites. In this report, we document a rare instance in which this neoplasm besides affecting the bone marrow also involved the lung. In addition, the lymphoma in our case disclosed CD10 positivity on immunohistochemistry and t(8;14)(q24;q34) translocation on cytogenetic analysis, mimicking a Burkitt/atypical Burkitt lymphoma. The problems in diagnosis are discussed.

Key Words: plasmablastic lymphoma • bone marrow • lung • CD10 • t(8;14)(q24;q34)

This version was published on April 1, 2009

International Journal of Surgical Pathology, Vol. 17, No. 2, 163-166 (2009)
DOI: 10.1177/1066896908316785
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