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International Journal of Surgical Pathology
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Osseous Metaplasia of the Colon in a Diversion Proctocolitis

Kim Billingham, MB BCh

Department of Cellular Pathology, Southmead Hospital, Bristol, Avon, kim.billingham{at}blueyonder.co.uk

Miroslav Radojkovic, MD

Department of Cellular Pathology, Great Western Hospital, Swindon UK

Osseous metaplasia within the gastrointestinal tract is a rare phenomenon, seen most frequently in mucinproducing left-sided colonic adenocarcinomas. It has also been documented in a variety of benign conditions, occurring in polyps and lesions associated with inflammation and ulceration. This is the first case report, to the authors' knowledge, of osseous metaplasia associated with a diversion proctocolitis. The diversion was performed following stricture formation, secondary to complicated diverticular disease with diverticular phlegmon formation. In common with other cases, in which osseous metaplasia arises within a background of inflammation, the present case demonstrated stromal fibroblastic proliferation. The underlying pathogenesis of osseous metaplasia has not yet been elucidated, but secretion of various bone morphogenic proteins (belonging to the transforming growth factor-β superfamily) and increased alkaline phosphatase activity by both epithelial and stromal cells have been documented.

Key Words: osseous metaplasia • gastrointestinal tract • diversion proctocolitis

This version was published on February 1, 2009

International Journal of Surgical Pathology, Vol. 17, No. 1, 81-83 (2009)
DOI: 10.1177/1066896908315753
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