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Thymoma and Thymic Carcinoma Arising in a Thymolipoma: Report of a Unique Case

Department of Pathology, King Hussein Cancer Center, Amman, Jordan

Amani Joudeh, MD

Department of Pathology, King Hussein Cancer Center, Amman, Jordan

Hani El-Taani, MD

Department of Medicine, King Hussein Cancer Center, Amman, Jordan

Asem Mansour, MD

Department of Radiology, King Hussein Cancer Center, Amman, Jordan

Basem Morcos, MD

Department of Surgery, King Hussein Cancer Center, Amman, Jordan

Said Fayoumi, MD

Department of Surgery, King Hussein Cancer Center, Amman, Jordan

Maher Sughayer, MD

Department of Pathology, King Hussein Cancer Center, Amman, Jordan, msughayer{at}khcc.jo

Thymic carcinoma arising within a thymolipoma has not been reported previously. The authors present a unique case of thymoma and undifferentiated thymic carcinoma arising within a thymolipoma in a 36-year-old woman. The bulk of the resected mass was composed of benign fatty tissue admixed with foci of unremarkable thymic tissue; however, it also harbored a central solid mass showing undifferentiated thymic carcinoma associated with a type B2 thymoma. The carcinoma cells were positive for cytokeratin AE1/AE3, cytokeratin 19, and cytokeratin 8/18. They were negative for vimentin, cytokeratin 7, cytokeratin 20, CD5, epithelial membrane antigen, CD30, placental alkaline phosphatase, carcinoembryonic antigen, CD99, leukocyte common antigen, Epstein-Barr virus, inhibin alpha, and protein gene product 9.5. Rare tumor cells showed positive staining for chromogranin and synaptophysin.

Key Words: thymic carcinoma • thymolipoma • thymoma • immunostains

This version was published on February 1, 2009

International Journal of Surgical Pathology, Vol. 17, No. 1, 55-59 (2009)
DOI: 10.1177/1066896908315822


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