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International Journal of Surgical Pathology
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Del(5q) Is Associated With Clinical and Histological Parameters in Small Cell Neuroendocrine Lung Carcinoma

Paul H. Hartel, MD

Department of Pathology, West Virginia University, Health Sciences North, Morgantown, West Virginia, hartelp{at}davishealthsystem.org

Amy L. Shackelford, CLSp CG

Department of Pathology, West Virginia University, Health Sciences North, Morgantown, West Virginia

James V. Hartel, MD

Department of Pathology, West Virginia University, Health Sciences North, Morgantown, West Virginia

Sharon L. Wenger, PhD

Department of Pathology, West Virginia University, Health Sciences North, Morgantown, West Virginia

To elucidate the relationship between del(5q) and the clinical and histological features of small cell neuroendocrine lung carcinoma, 33 tissue samples from patients with this tumor were evaluated. By using fluorescence in situ hybridization, del(5q) was identified in almost 50% of cases (15/33, 45%). Clinically, patients with tumors showing del(5q) were older (mean age = 71 years) with a correspondingly greater pack-year smoking history (mean = 61) than patients with tumors (mean age = 59 years, mean pack-years = 44) without del(5q). Histologically, tumors with del(5q) had a greater frequency of spindle cell morphology (11/14 [79%] vs 6/16 [38%], P < .025) than those without del(5q). This is the first study to find an association between del(5q) and tumor histology in small cell neuroendocrine lung carcinoma.

Key Words: chromosome • 5q • small cell • neuroendocrine • lung cancer • spindle cell

This version was published on October 1, 2008

International Journal of Surgical Pathology, Vol. 16, No. 4, 419-423 (2008)
DOI: 10.1177/1066896908318935
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