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Expression of Telomeric Repeat Binding Factor 1 Protein in Nonsmall Cell Lung Cancer With Human Telomerase Reverse Transcriptase Positive

Department of Thoracic and Cardiovascular Surgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, Department of Thoracic and Cardiovascular Surgery, Hangzhou First People's Hospital, hjsl{at}mail.hz.zj.cn

Sun Li, MD

School of Medical, Hangzhou Normal University X-L), Hangzhou, China

Zhang Chong, MD

Department of Thoracic and Cardiovascular Surgery, the First Affiliated Hospital, College of Medicine, Zhejiang University

Xie-Lai Zhou, MD

School of Medical, Hangzhou Normal University X-L), Hangzhou, China

Telomeric repeat binding factor 1 plays pivotal roles in telomere protection and maintenance in mammalian cells. In this article, the expression of telomeric repeat binding factor 1 protein in nonsmall cell lung cancer with human telomerase reverse transcriptase positive is investigated, and the relationship between the telomeric repeat binding factor 1 and clinic factors is analyzed. The expressions of human telomerase reverse transcriptase were detected by immunohistochemistry. The levels of telomeric repeat binding factor 1 protein were measured by Western blot. In all, 72% (36/50) patients showed human telomerase reverse transcriptase positive. Telomeric repeat binding factor 1 expression of cancer tissues and paired noncancerous tissues in 30 cases of human telomerase reverse transcriptase positive was 0.552 ± 0.329 and 0.654 ± 0.476, respectively (P < .05). No significant difference in telomeric repeat binding factor 1 protein expression was observed among sex, clinical stages, pathological subtypes, and lymph node metastasis. The results indicated that down-regulation of telomeric repeat binding factor 1 expression appeared in lung cancer tissue, and no correlation was found between telomeric repeat binding factor 1 expression and clinicopathologic factors.

Key Words: nonsmall cell lung cancer • telomeric repeat binding factor 1 • telomerase reverse transcriptase • immunohistochemistry • Western blot

This version was published on October 1, 2008

International Journal of Surgical Pathology, Vol. 16, No. 4, 414-418 (2008)
DOI: 10.1177/1066896908315755


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