Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
International Journal of Surgical Pathology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ni Wayan Winarti
Right arrow Articles by Mulyadi, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ni Wayan Winarti,
Right arrow Articles by Mulyadi, K.
Right arrowPubmed/NCBI databases
Medline Plus Health Information
*Kidney Cancer
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Pediatric Renal Cell Carcinoma Associated With Xp11.2 Translocation/TFE3 Gene Fusion

Ni Wayan Winarti, MD

Department of Pathology, Medical Faculty of Udayana University, Denpasar, Bali, Indonesia, yanawantara{at}yahoo.com

Pedram Argani, MD

Surgical Pathology, Johns Hopkins Hospital, Baltimore, Maryland

Angelo M. De Marzo, MD, PhD

Surgical Pathology, Johns Hopkins Hospital, Baltimore, Maryland

Jessica Hicks, BA

Surgical Pathology, Johns Hopkins Hospital, Baltimore, Maryland

Ketut Mulyadi, MD

Department of Pathology, Medical Faculty of Udayana University, Denpasar, Bali, Indonesia

Renal cell carcinoma (RCC) in children and young adults is rare and pathologically problematic. RCC can be either hereditary or sporadic and has a guarded prognosis because appropriate management has not been established. A case of RCC in an 11-year-old is reported. The clinical presentation was a right abdominal mass, hematuria, urinary tract infection, and wasting. Radio-logically, the mass was found within the right kidney with calcification and paraaortic lymphadenopathy. The postsurgical diagnosis was Wilms' tumor stage T4N2M0. On gross inspection, the tumor was ill defined, extending across Gerota's fascia and into the ureter lumina. Microscopically, the tumor consisted of malignant epithelial cells with clear and eosinophilic cytoplasm in nested, papillary, and alveolar configuration. Hyaline nodules, psammoma bodies, vascular invasion, capsular invasion, and extension into the ureter were also found. Immunohistochemically, the cells showed strong nuclear immunoreactivity for TFE3. We concluded that this case was an RCC associated with Xp11.2 translocation/TFE3 fusion, Fuhrman grade 3, stage IV.

Key Words: Xp11 translocation carcinoma • morphology • immunohistochemistry

International Journal of Surgical Pathology, Vol. 16, No. 1, 66-72 (2008)
DOI: 10.1177/1066896907304994
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?