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International Journal of Surgical Pathology
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Mesothelial Glandular Structures Within Pseudosarcomatous Proliferative Funiculitis—A Diagnostic Pitfall: Report of 17 Cases

Michal Michal, MD

Sikl's Department of Pathology, Laboratore Spec. Diagnostiky Medical Faculty Hospital, Plzen, Czech Republic, michal{at}medima.cz

Ondrej Hes, MD

Sikl's Department of Pathology, Laboratore Spec. Diagnostiky Medical Faculty Hospital, Plzen, Czech Republic

Dmitry V. Kazakov, MD

Sikl's Department of Pathology, Laboratore Spec. Diagnostiky Medical Faculty Hospital, Plzen, Czech Republic

We describe 17 cases of distinct benign pseudomalignant mesothelial proliferations, involving the spermatic cord. All cases revealed necrosis. The areas adjacent to the necrotic tissue comprised a cellular spindle cell proliferation with a haphazard arrangement of the myofibroblasts that in many areas revealed transitions into plump oval epithelioid cells and into cells with genuine epithelial appearances arranged in linear cords and often luminized into small microcysts. These epithelial cells formed isolated groups with glandular structures arising on the myofibroblastic background. Glandular structures were often situated deeply in the stroma of the spermatic cords. All cellular elements were strongly positive with AE1/AE3 antibody. All myofibroblasts stained with SM-actin antibody. Ultrastructurally, the spindle cells displayed features of myofibroblasts including actin microfilaments, as did the plump epithelioid cells that, additionally, had desmosomes, and the cords of the epithelial cells including those forming glandular structures had characteristics of mesothelias including the characteristic microvilli.

Key Words: pseudosarcomatous myofibroblastic proliferation • proliferative funiculitis • testis • mesothelial glandular inclusions • adenomatoid tumor

International Journal of Surgical Pathology, Vol. 16, No. 1, 48-56 (2008)
DOI: 10.1177/1066896907307235
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