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International Journal of Surgical Pathology
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Immunohistochemical Expression of Estrogen Receptors in Chondrosarcomas and Enchondromas

Thomas J. Grifone, MD

Department of Pathology, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia

Helen M. Haupt, MD

Department of Pathology, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia, haupth{at}pahosp.com

Victoria Podolski, BS, MT ASCP

Department of Pathology, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia

John J. Brooks, MD

Department of Pathology, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia

Immunohistochemical expression of estrogen receptors {alpha} and β was studied in chondrosarcomas and enchondromas and was correlated with chondrosarcoma grade, type, and dedifferentiation. Estrogen receptor {alpha} was studied in 37 chondrosarcomas, 10 enchondromas, and 2 extraskeletal myxoid chondrosarcomas. Estrogen receptor β was studied in 23 chondrosarcomas, 6 enchondromas, and 2 extraskeletal myxoid chondrosarcomas. Ventana prediluted monoclonal anti-ER {alpha} (clone 6F11) and Biogenex prediluted polyclonal anti-ER β were used on the Ventana ES autostainer and BenchMark XT IHC/ISH, respectively. Percent of cell staining and intensity (+, ++, or +++) was evaluated. Overall, 61% of conventional chondrosarcoma and 60% of enchondroma were positive for estrogen receptor {alpha}. Low-grade chondrosarcoma expressed estrogen receptor {alpha} more frequently than high-grade chondrosarcoma (P ≤ .001). Extraskeletal myxoid chondrosarcomas expressed estrogen receptor {alpha}; it was not expressed in dedifferentiated chondrosarcoma. Overall, 89% of conventional chondrosarcomas and 83% of enchondromas were positive for estrogen receptor β. Low-grade chondrosarcomas expressed estrogen receptor β more frequently than high-grade chondrosarcomas (P ≤ .05). Extraskeletal myxoid chondrosarcomas expressed estrogen receptor β; it was frequently lost in dedifferentiated chondrosarcoma.

Key Words: chondrosarcoma • enchondroma • estrogen receptor {alpha} • estrogen receptor β • immunohistochemical

International Journal of Surgical Pathology, Vol. 16, No. 1, 31-37 (2008)
DOI: 10.1177/1066896907306774
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