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International Journal of Surgical Pathology
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Expression of p21Cip1/Waf1 and p27Kip1 in Small Cell Neuroendocrine Carcinoma of the Uterine Cervix

Tatsuki R. Kataoka, MD

Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Department of Pathology, Medical School/Graduate School of Frontier Bioscience, Osaka University, Osaka, Japan, kataokat{at}niaid.nih.gov

Yoshitane Tsukamoto, MD

Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka

Makiko Matsumura, MD

Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka

Asako Miyake, MD

Department of Gynecology Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka

Shoji Kamiura, MD

Department of Gynecology Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka

Shingo Ishiguro, MD

Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka

Yasuko Nishizawa, MD

Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Laboratory of Clinical and Experimental Pathophysiology Graduate School of Pharmaceutical Science, Osaka University, Osaka, Japan

Small-cell neuroendocrine carcinoma of the uterine cervix (SCCC), a rare but malignant cervical neoplasm, has a highly aggressive phenotype that requires more intensive treatment than other cervical tumors. Immunohistochemical methods were used to compare the expression of p21Cip1/Waf1 and p27Kip1 in SCCC and squamous cell carcinoma, the most common type of cervical cancer. In SCCC, p21 expression was significantly reduced compared with squamous cell carcinoma, whereas expression of p27 was similar in both carcinomas. Reduced expression of p21 could be a helpful diagnostic marker and may contribute to the invasive phenotype of SCCC.

Key Words: p21Cip1/Waf1 • p27Kip1 • p53 • small cell neuroendocrine carcinoma • uterine cervix

International Journal of Surgical Pathology, Vol. 16, No. 1, 11-15 (2008)
DOI: 10.1177/1066896907309574
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