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International Journal of Surgical Pathology
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Article

Lymphangiogenetic Characteristics of Triple Negativity in Node-Negative Breast Cancer

Huan-Tao Liu*, Rong Ma, Qi-Feng Yang, Gang Du, and Cui-Juan Zhang

* To whom correspondence should be addressed. E-mail: htliu09{at}163.com.


  Abstract
Purpose. Triple-negativity breast cancer (TNBC), being negative for the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor 2, represents a subgroup of breast cancer with a poor clinical outcome. The aim of the study was to determine whether TNBC is associated with lymphangiogenesis in node-negative breast carcinomas. Methods. The authors investigated the clinicopathologic characteristics, lymphatic vessel density (LVD), and expression of 2 lymphangiogenetic factors, vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor D (VEGF-D), in 21 lymph node–negative TNBCs and 70 lymph node–negative non-TNBCs. Results. TNBC correlated with younger age (below 35 year) and higher histological grade. It also correlated with a higher intratumoral and peritumoral LVD, positive lymphatic invasion, and positive VEGF-C and VEGF-D expression. Conclusions. For the first time, this study indicated a link between triple-negativity breast cancer and lymphangiogenesis. Lymphangiogenesis might help explain the special malignant phonotype of breast cancer, and lymphangiogenesis inhibitors might be a novel choice for triple-negativity breast cancer patients.

First published on June 3, 2009
International Journal of Surgical Pathology 2009, doi:10.1177/1066896909337505
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