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International Journal of Surgical Pathology
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Article

Skin-Type Adnexal Tumor With Trichoblastic Germinative Differentiationin the Breast: A Case Report

Özay Gököz, Loretta Presenti, Giuseppina Gambacorta, Federica Zolfanelli, Rossella Tricarico, Roberto Nistri, Gianna Baroni, Simonetta Bianchi, and Daniela Massi*

* To whom correspondence should be addressed. E-mail: daniela.massi{at}unifi.it.


  Abstract
Adnexal tumors with follicular differentiation in the breast parenchyma are rarely encountered. The authors present a unique case arising in a 64-year-old woman, in whom they observed composite differentiation toward follicular germinative cells of the hair follicle with focal areas of outer root sheath differentiation and pilar-type keratinization. The histogenesis of this tumor is analyzed in light of the peculiar pathological, immunohistochemical, and molecular genetic findings.

First published on May 25, 2009
International Journal of Surgical Pathology 2009, doi:10.1177/1066896909337383
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