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International Journal of Surgical Pathology
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Article

Pgp 9.5 and Cyclin D1 Co-Expression in Cutaneous Squamous Cell Carcinomas

Aikaterini Mastoraki*, Eleftherios Ioannidis, Aikaterini Apostolaki, Efstratios Patsouris, and Kiriaki Aroni

* To whom correspondence should be addressed. E-mail: dr_kamast{at}yahoo.gr.


  Abstract
Background: squamous cell carcinoma (SCC) consists of altered keratinocytes, presents variable differentiation, inexorably progresses, and on occasion metastasizes. Objective: to investigate the biological activity of epidermal cells in SCCs by estimating the expression of PGP 9.5 and cyclin D1 using immunohistochemistry. Methods: the sample included 13 well-differentiated cases of cutaneous SCC (grade I), 12 moderately differentiated tumors (grade II), and 7 poorly differentiated lesions (grade III). Four cases belonged to the distinct entity of pseudoadenoid SCC. Results: PGP 9.5 expression was positively correlated with tumor stage (P < .001) and potential perineural invasion (P < .001), whereas cyclin D1 expression correlated inversely with the degree of cellular differentiation (P < .001) and PGP 9.5 immunostaining (P < .001). Conclusion: PGP 9.5 and cyclin D1 coexpression was closely associated with tumor aggressiveness and can be classified as a marker for predicting the outcome of resection-treated skin cancer patients.

First published on May 14, 2009
International Journal of Surgical Pathology 2009, doi:10.1177/1066896909336018
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