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International Journal of Surgical Pathology
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Article

HER-2 Protein Overexpressed Breast Cancer Without Gene Amplification Shows Higher Hormone Receptor Expression Than HER-2 Protein Overexpressed Breast Cancer With Gene Amplification

Ja Seung Koo, Woohee Jung, and Woo Ick Yang*

* To whom correspondence should be addressed. E-mail: wiyang9660{at}yuhs.ac.


  Abstract
Cases of breast cancer showing human epidermal growth factor receptor-2 (HER-2) protein overexpression without corresponding gene amplification have been found in immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH) results. We investigated the clinicopathological characteristics of cases showing HER-2 protein overexpression breast cancer without gene amplification (IHC3+/FISH–) and compared them to cases showing HER-2 protein overexpression breast cancer with gene amplification (IHC3+/ FISH+). This study was conducted on 90 patients with HER-2 IHC3+ breast cancer. The clinicopathological factors analyzed included tumor size, histological grade, nuclear grade, nodal involvement, and hormone receptor status. HER-2 IHC3+/FISH– breast cancer was found in 14 of 84 tumors (16.7%) and showed a statistically significant lower histological and nuclear grade (P = .000) and higher expression of estrogen receptors (ERs) and progesterone receptors (PRs) (P = .006) than IHC3+/FISH+ breast cancer. In conclusion, HER-2 IHC3+/FISH– breast cancer could be a subgroup showing lower histological/nuclear grade and higher expression of ERs/PRs.

First published on August 10, 2009
International Journal of Surgical Pathology 2009, doi:10.1177/1066896909335821
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